Making MSCs GMP: A Compliant Workflow

16

October

  • 3pm London 10am New York
  • Free
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Why attend?

Mesenchymal stem cells (MSCs) have long held therapeutic value due to their self-regeneration, differentiation, and immunomodulation properties. Manufacturing MSCs at scale and under GMP compliance has been a challenge however, largely due to materials such as coating reagents. Here, Terumo Blood and Cell Technologies and Akron Bio have partnered to develop a GMP-compliant MSC manufacturing workflow that is closed, automated, and scalable.

Key Takeaways:

  • Full MSC workflow with research and GMP-grade fibronectin
  • MSC harvest yields, doubling times, and expression of ISCT flow cytometry standard markers
  • Trilineage differentiation results as assessed by MSC morphology

Speakers

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Trevor Smith, MS MBA
Senior Marketing Manager for Cell & Gene Therapy in North America- Terumo Blood and Cell Technologies

Trevor has worked extensively in cell and gene therapy and has published methods of T cell expansion on automated bioreactor systems. He has a deep understanding of how to scale-up therapies through process development, GMP lab design, personnel training, and optimized cell collections. In his current role, he uses this knowledge and his immunology background to help customers commercialize new therapies that will provide better patient outcomes.

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Nate Frank
Laboratory Scientist IV- Terumo Blood and Cell Technologies

Nate has more than a decade of experience optimizing parameters for cell and gene therapy production and scale-up.  He has specialized expertise in hollow fiber bioreactor process development for a range of cell types aimed at various applications in regenerative medicine and immunotherapy.  He is a two-time National Science Foundation fellow and has a passion for teaching and communicating science to a wide range of audiences from established professionals to middle and high school students who are just beginning their scientific journey.  He is a native of Colorado and enjoys backpacking in the backcountry in all four seasons and spending time with his family.

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